This gene encodes the pro-alpha2 chain of type I collagenwhose triple helix comprises two alpha1 chains and one alpha2chain. Type I is a fibril-forming collagen found in most connectivetissues and is abundant in bone, cornea, dermis and tendon.Mutations in this gene are associated with osteogenesis imperfectatypes I-IV, Ehlers-Danlos syndrome type VIIB, recessiveEhlers-Danlos syndrome Classical type, idiopathic osteoporosis, andatypical Marfan syndrome. Symptoms associated with mutations inthis gene, however, tend to be less severe than mutations in thegene for the alpha1 chain of type I collagen (COL1A1) reflectingthe different role of alpha2 chains in matrix integrity. Threetranscripts, resulting from the use of alternate polyadenylationsignals, have been identified for this gene. [provided by R.Dalgleish].

Titration of the COL1A2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 16-43 from the human protein was used as the immunogen for this COL1A2 antibody.

Aliquot the COL1A2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.