This gene is overexpressed in breast cancer and squamouscell carcinomas of the head and neck. The encoded protein islocalized in the cytoplasm and in areas of the cell-substratumcontacts. This gene has two roles: (1) regulating the interactionsbetween components of adherens-type junctions and (2) organizingthe cytoskeleton and cell adhesion structures of epithelia andcarcinoma cells. During apoptosis, the encoded protein is degradedin a caspase-dependent manner. The aberrant regulation of this genecontributes to tumor cell invasion and metastasis. Three splicevariants that encode different isoforms have been identified forthis gene.

Titration of the Cortactin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Purified His-tagged Cortactin protein fragment was used to produced this monoclonal Cortactin antibody.

Aliquot the Cortactin antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.