The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation.

Titration of the CPT1A antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 606-636 from the human protein was used as the immunogen for this CPT1A antibody.

Aliquot the CPT1A antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.