Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Titration of the CREB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

This CREB1 antibody was produced from a mouse immunized with a recombinant protein from human CREB1.

Aliquot the CREB1 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.