This antibody recognizes a protein of 36kDa, identified as Cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo.About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression. The antibody is useful in identifying mantle cell lymphomas (Cyclin D1 positive) from CLL/SLL and follicular lymphomas (Cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

The dilution stated for each application is a general starting point.Variations in protocols, secondaries and substrates may require the CCND1/809 mAb to be titered up or down for optimal performance.

Human recombinant full length Cyclin D1 protein was used as the immunogen.

Store the Cyclin D1 antibody at 2-8°C.Conjugate is light sensitive, store in the dark.

Bcl-1, Bcl1