This gene encodes a member of the cytochrome P450superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drugmetabolism and synthesis of cholesterol, steroids and other lipids.The protein encoded by this gene localizes to the endoplasmicreticulum and its expression is induced by some polycyclic aromatichydrocarbons (PAHs), some of which are found in cigarette smoke.The enzyme"s endogenous substrate is unknown; however, it is ableto metabolize some PAHs to carcinogenic intermediates. Otherxenobiotic substrates for this enzyme include caffeine, aflatoxinB1, and acetaminophen. The transcript from this gene contains fourAlu sequences flanked by direct repeats in the 3" untranslatedregion.

Titration of the CYP1A2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 255-282 from the human protein was used as the immunogen for this CYP1A2 antibody.

Aliquot the CYP1A2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.