Desmoglein 1 (DSG1) is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

Optimal dilution of the Desmoglein antibody should be determined by the researcher.

A recombinant protein corresponding to the intracellular domain of human Desmoglein 1 was used as the immunogen for the Desmoglein antibody.

Store the Desmoglein antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).