This gene encodes a TBP- (TATA box-binding protein)associated phosphoprotein that represses both basal and activatedlevels of transcription. The encoded protein is phosphorylated invivo and this phosphorylation affects its interaction with TBP.This protein contains a histone fold motif at the amino terminus, aTBP-binding domain, and a glutamine- and alanine-rich region. Thebinding of DR1 repressor complexes to TBP-promoter complexes mayestablish a mechanism in which an altered DNA conformation,together with the formation of higher order complexes, inhibits theassembly of the preinitiation complex and controls the rate of RNApolymerase II transcription.

Titration of the DR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 83-112 from the human protein was used as the immunogen for this DR1 antibody.

Aliquot the DR1 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.