The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor has been shown to activateNF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through itsdeath domain, this receptor interacts with TRADD protein, which isknown to serve as an adaptor that mediates signal transduction ofTNF-receptors. Knockout studies in mice suggested that this geneplays a role in T-helper cell activation, and may be involved ininflammation and immune regulation.

Titration of the DR6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 356-385 from the human protein was used as the immunogen for this DR6 antibody.

Aliquot the DR6 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.