The lysosphingolipid sphingosine 1-phosphate (S1P)regulates cell proliferation, apoptosis, motility, and neuriteretraction. Its actions may be both intracellular as a secondmessenger and extracellular as a receptor ligand. S1P and thestructurally related lysolipid mediator lysophosphatidic acid (LPA)signal cells through a set of G protein-coupled receptors known asEDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1Preceptors; others (e.g., EDG2; MIM 602282) are LPAreceptors.

Titration of the EDG8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 219-247 from the human protein was used as the immunogen for this EDG8 antibody.

Aliquot the EDG8 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.