The protein encoded by this gene is a transmembraneglycoprotein that is a member of the protein kinase superfamily.This protein is a receptor for members of the epidermal growthfactor family. EGFR is a cell surface protein that binds toepidermal growth factor. Binding of the protein to a ligand inducesreceptor dimerization and tyrosine autophosphorylation and leads tocell proliferation. Mutations in this gene are associated with lungcancer. Multiple alternatively spliced transcript variants thatencode different protein isoforms have been found for this gene.

Titration of the EGF Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 1163-1191 from the human protein was used as the immunogen for this EGF Receptor antibody.

Aliquot the EGF Receptor antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.