This gene encodes a carcinoma-associated antigen and is amember of a family that includes at least two type I membraneproteins. This antigen is expressed on most normal epithelial cellsand gastrointestinal carcinomas and functions as a homotypiccalcium-independent cell adhesion molecule. The antigen is beingused as a target for immunotherapy treatment of human carcinomas.Mutations in this gene result in congenital tufting enteropathy.
Titration of the EpCAM antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 200-229 from the human protein was used as the immunogen for this EpCAM antibody.
Aliquot the EpCAM antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
