This gene encodes an estrogen receptor, a ligand-activatedtranscription factor composed of several domains important forhormone binding, DNA binding, and activation of transcription. Theprotein localizes to the nucleus where it may form a homodimer or aheterodimer with estrogen receptor 2. Estrogen and its receptorsare essential for sexual development and reproductive function, butalso play a role in other tissues such as bone. Estrogen receptorsare also involved in pathological processes including breastcancer, endometrial cancer, and osteoporosis. Alternative splicingresults in several transcript variants, which differ in their 5"UTRs and use different promoters.

Titration of the Estrogen Receptor alpha antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 246-273 from the human protein was used as the immunogen for this Estrogen Receptor alpha antibody.

Aliquot the Estrogen Receptor alpha antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.