The protein encoded by this gene is an adaptor moleculethat interacts with various cell surface receptors and mediatescell apoptotic signals. Through its C-terminal death domain, thisprotein can be recruited by TNFRSF6/Fas-receptor, tumor necrosisfactor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus itparticipates in the death signaling initiated by these receptors.Interaction of this protein with the receptors unmasks theN-terminal effector domain of this protein, which allows it torecruit caspase-8, and thereby activate the cysteine proteasecascade. Knockout studies in mice also suggest the importance ofthis protein in early T cell development.

Titration of the FADD antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 106-135 from the human protein was used as the immunogen for this FADD antibody.

Aliquot the FADD antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.