Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. [UniProt]

Titration of the FBXW7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

This FBXW7 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 133-167 amino acids from the N-terminal region of human FBXW7.

Aliquot the FBXW7 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.