Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.

Titration of the FIS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

This FIS1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 6-40 amino acids from the N-terminal region of human FIS1.

Aliquot the FIS1 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.