This gene encodes a multifunctional protein component ofthe heterogeneous nuclear ribonucleoprotein (hnRNP) complex. ThehnRNP complex is involved in pre-mRNA splicing and the export offully processed mRNA to the cytoplasm. This protein belongs to theFET family of RNA-binding proteins which have been implicated incellular processes that include regulation of gene expression,maintenance of genomic integrity and mRNA/microRNA processing.Alternative splicing results in multiple transcript variants.Defects in this gene result in amyotrophic lateral sclerosis type6.
Titration of the FUS antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 499-526 from the human protein was used as the immunogen for this FUS antibody.
Aliquot the FUS antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
