G6PD encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia.
Titration of the G6PD antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 297-326 from the human protein was used as the immunogen for this G6PD antibody.
Aliquot the G6PD antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
