Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5"-GAACCACCCA-3" which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. Is involved in the smoothened (SHH) signaling pathway.

Titration of the GLI2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.1. GLI-2 exists as five alternatively spliced isoforms of 133 kDa (isoform 1), 132 (2), 88 (3), 86 (4) and 168 kDa (isoform 5).

This GLI2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 1287-1321 amino acids from the C-terminal region of human GLI2.

Aliquot the GLI2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.