This gene belongs to the Ras oncogene family, whosemembers are related to the transforming genes of mammalian sarcomaretroviruses. The products encoded by these genes function insignal transduction pathways. These proteins can bind GTP and GDP,and they have intrinsic GTPase activity. This protein undergoes acontinuous cycle of de- and re-palmitoylation, which regulates itsrapid exchange between the plasma membrane and the Golgi apparatus.Mutations in this gene cause Costello syndrome, a diseasecharacterized by increased growth at the prenatal stage, growthdeficiency at the postnatal stage, predisposition to tumorformation, mental retardation, skin and musculoskeletalabnormalities, distinctive facial appearance and cardiovascularabnormalities. Defects in this gene are implicated in a variety ofcancers, including bladder cancer, follicular thyroid cancer, andoral squamous cell carcinoma. Multiple transcript variants, whichencode different isoforms, have been identified for this gene.

Titration of the H-RAS antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 146-176 from the human protein was used as the immunogen for this H-RAS antibody.

Aliquot the H-RAS antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.