Histones play a critical role in transcriptionalregulation, cell cycle progression, and developmental events.Histone acetylation/deacetylation alters chromosome structure andaffects transcription factor access to DNA. The protein encoded bythis gene belongs to the histone deacetylase/acuc/apha family. Ithas histone deacetylase activity and represses transcription whentethered to a promoter. It may participate in the regulation oftranscription through its binding with the zinc-fingertranscription factor YY1. This protein can also down-regulate p53function and thus modulate cell growth and apoptosis. This gene isregarded as a potential tumor suppressor gene. [provided byRefSeq].
Titration of the HDAC3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 383-412 from the human protein was used as the immunogen for this HDAC3 antibody.
Aliquot the HDAC3 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
