HDAC6 (histone deacetylase 6) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.HDAC6 plays a central role in microtubule-dependent cell motility via deacetylation of tubulin, and has been shown to interact with HDAC11, SIRT2, and F-actin. HDAC6 is ubiquitinated, but its polyubiquitination however does not lead todegradation. HDAC is also a potential target of sumoylation.

Titration of the HDAC6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 1182-1215 from the human protein was used as the immunogen for this HDAC6 antibody.

Aliquot the HDAC6 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.