Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Titration of the Histone H3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

This Histone H3 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 8~39 amino acids from human.

Aliquot the Histone H3 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.