Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. Nucleosomes consist of approximately 146 bp of DNAwrapped around a histone octamer composed of pairs of each of thefour core histones (H2A, H2B, H3, and H4). The chromatin fiber isfurther compacted through the interaction of a linker histone, H1,with the DNA between the nucleosomes to form higher order chromatinstructures. This gene is intronless and encodes a member of thehistone H2B family. Two transcripts that encode the same proteinhave been identified for this gene, which is found in the largehistone gene cluster on chromosome 6p22-p21.3. [provided byRefSeq].

Titration of the HIST1H2BD antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 1-30 from the human protein was used as the immunogen for this HIST1H2BD antibody.

Aliquot the HIST1H2BD antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.