DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity). [UniProt]
Titration of the HMGB-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 152-180 from the human protein was used as the immunogen for this HMGB-1 antibody.
Aliquot the HMGB-1 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
HMG1
