Heat Shock Protein 90 is a molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. [UniProt]

Titration of the HSP90 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids from 150-400 of the human protein were used as the immunogen for this HSP90AA1 antibody.

Aliquot the HSP90 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.