The protein encoded by this gene is a member of theintercellular adhesion molecule (ICAM) family. All ICAM proteinsare type I transmembrane glycoproteins, contain 2-9immunoglobulin-like C2-type domains, and bind to the leukocyteadhesion LFA-1 protein. This protein is constitutively andabundantly expressed by all leucocytes and may be the mostimportant ligand for LFA-1 in the initiation of the immuneresponse. It functions not only as an adhesion molecule, but alsoas a potent signalling molecule.
Titration of the ICAM3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 282-310 from the human protein was used as the immunogen for this ICAM3 antibody.
Aliquot the ICAM3 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
CD50
