This antibody is specific to Insulin-like Growth Factor (IGF-1) and shows minimal cross-reaction with IGF-11, Proinsulin, MSF, and Insulin. IGF-1 is a polypeptide growth factor with two isoforms that are produced by alternative splicing. Isoform 1 is also known as IGF-IB while isoform 2 is known as IGF-IA. IGF-1 stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It functions as an autocrine regulator of growth. Activation of IGF system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like those of breast, thyroid and colon.

Optimal dilution of the IGF-1 antibody should be determined by the researcher.

Full-length recombinant human IGF1 protein was used as the immunogen for the IGF-1 antibody.

Store the IGF-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).