This gene encodes an immunoregulatory cytokine producedprimarily by activated Th2 cells. This cytokine is involved inseveral stages of B-cell maturation and differentiation. Itup-regulates CD23 and MHC class II expression, and promotes IgEisotype switching of B cells. This cytokine down-regulatesmacrophage activity, thereby inhibits the production ofpro-inflammatory cytokines and chemokines. This cytokine is foundto be critical to the pathogenesis of allergen-induced asthma butoperates through mechanisms independent of IgE and eosinophils.This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster onchromosome 5q, with this gene particularly close to IL4. [providedby RefSeq].

Titration of the IL-13 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 118-146 from the human protein was used as the immunogen for this IL-13 antibody.

Aliquot the IL-13 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.