The protein encoded by this gene is a cytokine receptorthat belongs to the interleukin 1 receptor family. This proteinbinds interleukin alpha (IL1A), interleukin beta (IL1B), andinterleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoyreceptor that inhibits the activity of its ligands. Interleukin 4(IL4) is reported to antagonize the activity of interleukin 1 byinducing the expression and release of this cytokine. This gene andthree other genes form a cytokine receptor gene cluster onchromosome 2q12. Two alternatively spliced transcript variantsencoding the same protein have been reported.

Titration of the IL1R2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 273-300 from the human protein was used as the immunogen for this IL1R2 antibody.

Aliquot the IL1R2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.