ITGA1 is the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.

Titration of the Integrin alpha 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 727-755 from the human protein was used as the immunogen for this Integrin alpha 1 antibody.

Aliquot the Integrin alpha 1 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.