The product of this gene belongs to the integrin betachain family of proteins. Integrins are integral cell-surfaceproteins composed of an alpha chain and a beta chain. This geneencodes the integrin beta chain beta 2. A given chain may combinewith multiple partners resulting in different integrins. Forexample, beta 2 combines with the alpha L chain to form theintegrin LFA-1, and combines with the alpha M chain to form theintegrin Mac-1. Integrins are known to participate in cell adhesionas well as cell-surface mediated signalling. Defects in this geneare the cause of leukocyte adhesion deficiency type I (LAD1). Twotranscript variants encoding the same protein have been identifiedfor this gene.

Titration of the Integrin beta 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Purified His-tagged protein fragment was used to produced this monoclonal Integrin beta 2/CD18 antibody.

Aliquot the Integrin beta 2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.