Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. ILK encodes a predicted 451-amino acid protein, with an apparent molecular weight of 59 kD. The ILK protein is a serine/threonine protein kinase with 4 ankyrin-like repeats. ILK regulates integrin-mediated signal transduction.

Titration of the Integrin linked kinase antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 11-41 from the mouse protein was used as the immunogen for this Integrin linked kinase antibody.

Aliquot the Integrin linked kinase antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.