This mAb is specific for human interferon alpha 1 and does not cross react with human interferon alpha 2. Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon- & Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.

Optimal dilution of the Interferon alpha antibody should be determined by the researcher.

1. This clone is also referred to as clone 2-52.

Purified recombinant human protein was used as the immunogen for the Interferon alpha antibody.

Store the Interferon alpha antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).