Required for innate immune defense against viruses. Acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis (By similarity).

Titration of the Ips-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 1-30 from the mouse protein was used as the immunogen for this Ips-1 antibody.

Aliquot the Ips-1 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.