The protein encoded by this gene belongs to the IRF(interferon regulatory factor) family of transcription factors,characterized by an unique tryptophan pentad repeat DNA-bindingdomain. The IRFs are important in the regulation of interferons inresponse to infection by virus, and in the regulation ofinterferon-inducible genes. This family member is lymphocytespecific and negatively regulates Toll-like-receptor (TLR)signaling that is central to the activation of innate and adaptiveimmune systems. A chromosomal translocation involving this gene andthe IgH locus, t(6;14)(p25;q32), may be a cause of multiplemyeloma. Alternatively spliced transcript variants have been foundfor this gene.
Titration of the IRF4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 164-191 from the human protein was used as the immunogen for this IRF4 antibody.
Aliquot the IRF4 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
