KDR is a major growth factor for endothelial cells. This protein encodes one of the two receptors of the KDR. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc..

Titration of the KDR antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 1153-1182 from the human protein was used as the immunogen for this KDR antibody.

Aliquot the KDR antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.