This antibody recognizes a dimer of two proteins of 70kDa (Ku70) and ~80kDa (Ku80), identified as two subunits of Ku. Antbody KU729 recognizes a conformational epitope of the Ku70 + Ku80 dimer, which is destroyed during Western blotting.The Ku70 + Ku80 dimer is important for function of a 460kDa DNA-dependent protein kinase.Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.

The concentration stated for each application is a general starting point.Variations in protocols, secondaries and substrates may require the Ku70 + Ku80 antibody to be titered up or down for optimal performance.

Nuclear extract of human HL-60 cells was used as the immunogen for this Ku70 + Ku80 antibody.

Store the Ku70 + Ku80 antibody at 2-8oC. Conjugate is light sensitive, store in the dark.

ATP dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; G22P1; Thyroid-lupus autoantigen (TLAA); X-ray repair cross-complementing protein 6 (XRCC6), ATP dependent DNA helicase 2 subunit 2; ATP dependent DNA helicase II 86 Kd subunit; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85kDa subunit; CTC85; CTCBF; KARP1; Nuclear factor IV (NFIV); Thyroid-lupus autoantigen (TLAA); X-ray repair cross-complementing protein 5 (XRCC5), Ku70 + Ku80 antibody