Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone. [UniProt]

The stated application concentrations are suggested starting points. Titration of the Lamin A/C antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Recombinant human LMNA was used as the immunogen for the Lamin A/C antibody.

Aliquot the LMNA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.