Serine/threonine kinase 11 or LKB1 is a protein kinase which in humans is encoded by the STK11 gene. The STK11 gene, which encodes a member of the serine/threonine kinase, regulates cell polarity and functions as a tumour suppressor. STK11 is a primary upstream kinase of adenine monophosphate-activated protein kinase (AMPK), a necessary element in cell metabolism that is required for maintaining energy homeostasis. It has been found that LKB1 physically associates with p53 and regulates specific p53-dependent apoptosis pathways.

Variations in secondary/substrate sensitivities and test protocols may require the LKB1 antibody to be titrated for optimal performance.

Human partial recombinant protein (AA 62-430) was used as the immunogen for this LKB1 antibody.

The lyophilized LKB1 antibody can be stored at 4oC to -20oC.After reconstitution, aliquot and store at -20oC.Avoid repeated freeze/thaws.