This gene encodes a member of the lysyl oxidase genefamily. The prototypic member of the family is essential to thebiogenesis of connective tissue, encoding an extracellularcopper-dependent amine oxidase that catalyses the first step in theformation of crosslinks in collagens and elastin. A highlyconserved amino acid sequence at the C-terminus end appears to besufficient for amine oxidase activity, suggesting that each familymember may retain this function. The N-terminus is poorly conservedand may impart additional roles in developmental regulation,senescence, tumor suppression, cell growth control, and chemotaxisto each member of the family. Alternatively spliced transcriptvariants of this gene have been reported but their full-lengthnature has not been determined.

Titration of the LOXL3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 715-744 from the human protein was used as the immunogen for this LOXL3 antibody.

Aliquot the LOXL3 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.