Liver X receptor alpha, also called NR1H3, is a tissue-specific cofactor that permits RXRA to function as a potent 9cRA receptor with a distinct target gene specificity. It specifically interacts with RXRA in vivo to form a functional heterodimer in which RXRA is the ligand-binding subunit. Additionally, Liver X receptor activity is critical for physiologic lipid metabolism and transport. They are endogenous inhibitors of atherogenesis and are targets for therapeutic intervention in cardiovascular disease. Furthermore, they and their ligands are negative regulators of macrophage inflammatory gene expression. Liver X receptors act as a transcriptional switch that integrates hepatic glucose metabolism and fatty acid synthesis. The LXR-IDOL-LDLR axis defines a complementary pathway to sterol response element-binding proteins for sterol regulation of cholesterol uptake.

The stated application concentrations are suggested starting amounts.Titration of the LXR alpha antibody may be required due to differences in protocols and secondary/substrate sensitivity.

An amino acid sequence from the C-terminus of human LXR alpha (NVQDQLQVERLQHTY) was used as the immunogen for this LXR alpha antibody (100% homologous in human, mouse and rat).

After reconstitution, the LXR alpha antibody can be stored for up to one month at4oC.For long-term, aliquot and store at -20oC.Avoid repeated freezing and thawing.