Proteins of the matrix metalloproteinase (MMP) family areinvolved in the breakdown of extracellular matrix in normalphysiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in diseaseprocesses, such as arthritis and metastasis. Most MMP"s aresecreted as inactive proproteins which are activated when cleavedby extracellular proteinases. This gene encodes an enzyme whichdegrades type IV collagen, the major structural component ofbasement membranes. The enzyme plays a role in endometrialmenstrual breakdown, regulation of vascularization and theinflammatory response. Mutations in this gene have been associatedwith Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO)syndrome. Two transcript variants encoding different isoforms havebeen found for this gene.

Titration of the MMP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 303-331 from the human protein was used as the immunogen for this MMP2 antibody.

Aliquot the MMP2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.