This gene is a member of the mucin family and encodes amembrane bound, glycosylated phosphoprotein. The protein isanchored to the apical surface of many epithelia by a transmembranedomain, with the degree of glycosylation varying with cell type. Italso includes a 20 aa variable number tandem repeat (VNTR) domain,with the number of repeats varying from 20 to 120 in differentindividuals. The protein serves a protective function by binding topathogens and also functions in a cell signaling capacity.Overexpression, aberrant intracellular localization, and changes inglycosylation of this protein have been associated with carcinomas.Multiple alternatively spliced transcript variants that encodedifferent isoforms of this gene have been reported, but thefull-length nature of only some has been determined. [provided byRefSeq].

Titration of the MUC-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 1176-1205 from the human protein was used as the immunogen for this MUC-1 antibody.

Aliquot the MUC-1 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.