The MUC1 alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity. [UniProt]

Titration of the MUC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 1202-1231 from the human protein was used as the immunogen for this MUC1 antibody.

Aliquot the MUC1 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.