MuSK activates signaling cascades responsible for many aspects of synapse formation, including the organization of the postsynaptic membrane, synapse-specific transcription, and presynaptic differentiation.MuSK also mediates agrin-induced aggregation of acetylcholine receptors at the mature vertebrate neuromuscular junction and also during synapse formation. It has been shown that a majority of AChR Ab-seronegative myasthenia gravis patients possess serum autoantibodies against MuSK.

Titration of the MUSK antibody may be required due to differences in protocols and secondary/substrate sensitivity.

This MUSK antibody was produced from rabbits immunized with humanMUSK recombinant protein.

Aliquot the MUSK antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.