MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of the gene encoding MYC have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt"s lymphomas, suggesting its importance in the normal function of this gene.

Titration of the Myc antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 36-65 from the human protein was used as the immunogen for this Myc antibody.

Aliquot the Myc antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.