The protein encoded by this gene is a lysosomal enzymethat cleaves terminal sialic acid residues from substrates such asglycoproteins and glycolipids. In the lysosome, this enzyme is partof a heterotrimeric complex together with beta-galactosidase andcathepsin A (the latter is also referred to as "protectiveprotein"). Mutations in this gene can lead to sialidosis, alysosomal storage disease that can be type 1 (cherry redspot-myoclonus syndrome or normosomatic type), which is late-onset,or type 2 (the dysmorphic type), which occurs at an earlier agewith increased severity.

Titration of the NEU1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 188-214 from the human protein was used as the immunogen for this NEU1 antibody.

Aliquot the NEU1 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.