The product of this gene is a component of the nuclearfactor of activated T cells DNA-binding transcription complex. Thiscomplex consists of at least two components: a preexistingcytosolic component that translocates to the nucleus upon T cellreceptor (TCR) stimulation, and an inducible nuclear component.Proteins belonging to this family of transcription factors play acentral role in inducible gene transcription during immuneresponse. The product of this gene is an inducible nuclearcomponent. It functions as a major molecular target for theimmunosuppressive drugs such as cyclosporin A. Five transcriptvariants encoding distinct isoforms have been identified for thisgene. Different isoforms of this protein may regulate inducibleexpression of different cytokine genes.
Titration of the NFATC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 898-927 from the human protein was used as the immunogen for this NFATC1 antibody. This sequence is specific to isoform C.
Aliquot the NFATC1 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
