NKIRAS1 is part of the Ras family and GTPase superfamily of proteins.Unlike other family members which have a glycine and glutamine residue at positions 13 and 65, NKIRAS1 (and 2) has leucines in these positions.

NKIRAS1 is a regulator of NF-kB activity via its inhibition of IkB (NFKBIB) degradation.IkB complexes with NF-kB, preventing nuclear translocation and subsequent signaling.By preventing or reducing IkB degradation, NKIRAS1 blocks NF-kB signaling activity.

Provided assay concentrations are suggestions only, NKIRAS1 antibody titration may be required for optimal results.

A recombinant protein fragment from the central region of NKIRAS1 was used as the immunogen for this antibody.

Aliquot the NKIRAS1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

kB-Ras1, I-kappa-B-interacting Ras-like Protein 1, NFKB inhibitor interacting Ras-like 1, KappaB-ras1